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In a very new review, we described the identification as well as characterization of a new atypical opioid receptor with one of a kind negative regulatory properties toward opioid peptides.one Our results confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is usually a broad-spectrum scavenge